Synthesis of a novel family of diterpenes and their evaluation as anti-inflammatory agents.
نویسندگان
چکیده
The synthesis and biological evaluation of a new family of diterpenes, represented by structures 2 and 3, is presented. These compounds constitute isomeric analogues of acanthoic acid (1) and were examined as potent anti-inflammatory agents. Among them, methyl ester 12 exhibited a low non-specific cytotoxicity, inhibited TNF-alpha synthesis and displayed good specificity in suppressing cytokine expression.
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ورودعنوان ژورنال:
- Bioorganic & medicinal chemistry letters
دوره 13 19 شماره
صفحات -
تاریخ انتشار 2003